Robert Powers
Professor Chemistry University of Nebraska-Lincoln
Contact
- Address
-
HAH 722
Lincoln NE 68588-0304 - Phone
-
402-472-3039 On-campus 2-3039
-
rpowers3@unl.edu
Research interests
NMR identification and quantification of cellular metabolite profiles in the presence of a variety of external stimuli is a powerful approach to examine molecular mechanisms and pathway flux in normal and diseased cells, tissues, organs, or biofluids. NMR methods can also be applied to examine protein conformational transitions, map protein-ligand or protein-protein docking interactions, and determine association/dissociation constants for such interactions. Research in Dr. Powers' laboratory is oriented toward development, validation, and application of new metabolite analysis techniques to examine disease mechanisms in collaboration with many labs at UNL, UNMC, and elsewhere. Students in his laboratory are currently working on projects that use bioinformatics, structural biology, and functional genomics to examine molecular docking, biofilm formation, assessment of drug activity and potency during and following inhibitor treatments in infectious disease and cancer models, and several other biochemical and biological questions. Much of Dr. Powers' work is directed at metabolomic analysis of human diseases.