Research interests

Mitochondria generate reactive oxygen species during respiration, but they are also highly sensitive to oxidative stress, buffered by specific mitochondrial protein quality control mechanisms. Research in the Khalimonchuk laboratory is focused on understanding the proteins that sense mitochondrial oxidative stress and how they regulate mitochondrial integrity. In particular, the Khalimonchuk laboratory uses yeast and mammalian cell culture models to examine inner mitochondrial membrane protein complexes sensitive to oxidative stress and the role of the oxidation-sensitive mitochondrial protease Oma1.

Publications     Khalimonchuk Lab