David Berkowitz
Professor Chemistry University of Nebraska-Lincoln
Contact
- Address
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HAH 824A
Lincoln NE 68588-0304 - Phone
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402-472-2738 On-campus 2-2738
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dberkowitz1@unl.edu
Research interests
Research in the Berkowitz laboratory is focused on the development of novel chemical and enzymatic methods to synthesize phosphoserine analogues, mechanism-based inhibitors, and mechanistic chemical probes for enzymes in amino acid synthesis and salvage pathways. Students in the Berkowitz lab are working on in-cell use of phosphoserine mimetics as probes for phosphatase activity, and have recently collaborated to create an enantioselective inhibitor of lysine decarboxylase and solve the x-ray crystal structure of the inactive complex.