Bill Velander
Professor Chemical & Biomolecular Engineering University of Nebraska-Lincoln
Contact
- Address
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OTHM 207B
Lincoln NE 68588-0643 - Phone
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402-472-3697 On-campus 2-3697
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wvelander2@unl.edu
Research interests
Blood coagulation factors are produced in abundance to treat human hemophilia A and B. Dr. Velander's laboratory uses the milk of transgenic pigs to produce recombinant factors VIII and IX, from which they can subsequently be purified. His group has extensively characterized factors produced by this method, which have relatively low specific activity, and has shown that differential N-glycan linkages during post-translational modification of the protein for secretion have a strong impact on function. Students in the Velander laboratory are working to identify novel subpopulations of the glycosylated proteins, which are purified, characterized in vitro, and preclinically studied in pharmacokinetic animal models. As a biomolecular engineer, Dr. Velander's expertise in the design and large-scale production of complex blood proteins is well complemented by research interests in the protein chemistry laboratories.