The integrity of metabolic processes is critical for the function of every cell and tissue and determines normal body mass maintenance, blood glucose homeostasis, neurological function, and other fundamental systemic coordination. Aberrant physiological and biochemical mechanisms that compromise metabolic integrity create an imposing national economic burden through health care costs and are accordingly a significant area of emphasis in NIH programming priorities. Mentors focused on lipid transport and trafficking, macromolecular clearance in the liver, and impacts of perturbations to these functions on body mass regulation, fatty liver, and reproductive function naturally complement mentors examining molecular signaling and disease microenvironment.
